SrasV1, Main, Exploration, bibRecord, 002358

Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model

Identifieur interne : 002358 ( Main/Exploration ); précédent : 002357; suivant : 002359

Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model

Auteurs : Yohichi Kumaki [États-Unis] ; Jane Ennis [Canada] ; Ramtin Rahbar [Canada] ; Jeffrey D. Turner [Canada] ; Miles K. Wandersee [États-Unis] ; Aaron J. Smith [États-Unis] ; Kevin W. Bailey [États-Unis] ; Zachary G. Vest [États-Unis] ; Jason R. Madsen [États-Unis] ; Joseph K.-K. L [États-Unis] ; Dale L. Barnard [États-Unis]

Source :

Antiviral research [ 0166-3542 ] ; 2011.

RBID : Pascal:11-0119722

Descripteurs français

Pascal (Inist)
- Dose unique, Voie intranasale, Adenoviridae, Animal, Souris, Interféron alpha, Mortalité, Virus syndrome respiratoire aigu sévère, Modèle animal, Cytokine, Thérapie génique, Syndrome respiratoire aigu sévère, Traitement, Prévention, Vecteur, Forme fatale.
Wicri :
- topic : Mortalité.

English descriptors

KwdEn :
- Adenoviridae, Alpha interferon, Animal, Animal model, Cytokine, Gene therapy, Intranasal administration, Mortality, Mouse, Prevention, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Single dose, Treatment, Vector.

Abstract

Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (p < 0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10⁶ to 10⁸ PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12 h post infection (p<0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections.

Affiliations:

Canada, États-Unis
Utah

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 000871
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to stream Main, to step Curation: 002358

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term>
<term>Alpha interferon</term>
<term>Animal</term>
<term>Animal model</term>
<term>Cytokine</term>
<term>Gene therapy</term>
<term>Intranasal administration</term>
<term>Mortality</term>
<term>Mouse</term>
<term>Prevention</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Single dose</term>
<term>Treatment</term>
<term>Vector</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Dose unique</term>
<term>Voie intranasale</term>
<term>Adenoviridae</term>
<term>Animal</term>
<term>Souris</term>
<term>Interféron alpha</term>
<term>Mortalité</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Modèle animal</term>
<term>Cytokine</term>
<term>Thérapie génique</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Traitement</term>
<term>Prévention</term>
<term>Vecteur</term>
<term>Forme fatale</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
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<front><div type="abstract" xml:lang="en">Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (p < 0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10<sup>6</sup>
 to 10<sup>8</sup>
 PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12 h post infection (p<0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections.</div>
</front>
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   |wiki=    Sante
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   |clé=     Pascal:11-0119722
   |texte=   Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
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Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model

Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model

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